Allopurinol

• Catalog No.: Bio-0799
• CAS Number: 315-30-0
• M. F.: C5H4N4O
• M. W.: 136.11146

SYNONYMS

• IUPAC name: 1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
• IUPAC Traditional name: 1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
• Synonyms: Progout; Zyloric; Zyloprim; Allosig; Allohexal

DATABASE IDS

• CAS Number: 315-30-0

PROPERTIES

• Application(s): Used in treatment of chronic gout and related diseases
• Application(s): Shows antithrombotic and antiparasitic activities
• Mechanism of Action: Xanthine oxidase inhibitor
• Mechanism of Action: Inhibitor of ATP synthesis from guanine and of RNA biosynthesis
• Mechanism of Action: Reported to protect adenine nucleotide pool.
• Mechanism of Action: Reported to decrease free-radical production
• Mechanism of Action: Reported free-radical-scavenger
• Mechanism of Action: Reported transition metal chelator
• Mechanism of Action: Urate-synthesis-inhibitor

REFERENCES

• Aldrich Library of NMR Spectra, 2nd edn., 1983, 2, 581C, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 708D, (ir)
• Robins, R.K., J.A.C.S., 1956, 78, 784, (synth)
• Thang, K.V. et al., C. R. Hebd. Seances Acad. Sci., 1969, 268, 525, (synth, ir)
• Hildick, B.G. et al., J.C.S.(C), 1971, 1610, (synth)
• Prusiner, P. et al., Acta Cryst. B, 1972, 28, 2148, (cryst struct)
• Benezra, S.A. et al., Anal. Profiles Drug Subst., 1978, 7, 1, (rev)
• Tisler, M. et al., Heterocycles, 1982, 17, 405, (synth)
• Wang, Y. et al., CA, 1983, 99, 105210, (synth)
• Marr, J.J., Adv. Exp. Med. Biol., 1985, 165A, 231, (rev, metab)
• Rundles, R.W., Arch. Intern. Med., 1985, 145, 1492, (rev, pharmacol, use)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 262, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 333
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ZVJ000