Nevirapine

• Catalog No.: Bio-0789
• CAS Number: 129618-40-2
• M. F.: C15H14N4O
• M. W.: 266.29786

SYNONYMS

• IUPAC name: 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
• IUPAC Traditional name: 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
• Synonyms: Viramune

DATABASE IDS

• CAS Number: 129618-40-2

PROPERTIES

• Application(s): Virucide
• Application(s): Used to treat HIV-1 infection and AIDS
• Mechanism of Action: Non-nucleoside reverse transcriptase inhibitor (NNRTI)

REFERENCES

• Merluzzi, V.J. et al., Science (Washington, D.C.), 1990, 250, 1411, (pharmacol)
• Eur. Pat., 1991, Boehringer Ingelheim, 429 987; CA, 115, 114559n, (synth, pharmacol)
• Cohen, K.A. et al., J. Biol. Chem., 1991, 266, 14670, (pharmacol)
• Koup, R.A. et al., J. Infect. Dis., 1991, 163, 966, (pharmacol)
• Hargrave, K.D. et al., J. Med. Chem., 1991, 34, 2231, (synth, pharmacol)
• Grob, P.M. et al., AIDS Res. Hum. Retroviruses, 1992, 8, 145, (pharmacol, rev)
• Merluzzi, V.J. et al., Adv. Exp. Med. Biol., 1992, 312, 89, (rev)
• Mui, P.W. et al., J. Med. Chem., 1992, 35, 201, (cryst struct)
• Skoog, M.T. et al., Med. Res. Rev., 1992, 12, 27, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1393
• Grozinger, K.G. et al., J. Het. Chem., 1995, 32, 259, (synth)
• Pedersen, O.S. et al., Synthesis, 2000, 479-495, (rev)