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Nevirapine

Catalog No. Bio-0789 Name InterBioScreen
CAS Number 129618-40-2 Website http://www.ibscreen.com
M. F. C15H14N4O Telephone +7 49652 40091
M. W. 266.29786 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 123

SYNONYMS

IUPAC name
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
IUPAC Traditional name
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
Synonyms
Viramune

DATABASE IDS

CAS Number 129618-40-2

PROPERTIES

Application(s) Virucide
Application(s) Used to treat HIV-1 infection and AIDS
Mechanism of Action Non-nucleoside reverse transcriptase inhibitor (NNRTI)

DETAILS

REFERENCES

  • Merluzzi, V.J. et al., Science (Washington, D.C.), 1990, 250, 1411, (pharmacol)
  • Eur. Pat., 1991, Boehringer Ingelheim, 429 987; CA, 115, 114559n, (synth, pharmacol)
  • Cohen, K.A. et al., J. Biol. Chem., 1991, 266, 14670, (pharmacol)
  • Koup, R.A. et al., J. Infect. Dis., 1991, 163, 966, (pharmacol)
  • Hargrave, K.D. et al., J. Med. Chem., 1991, 34, 2231, (synth, pharmacol)
  • Grob, P.M. et al., AIDS Res. Hum. Retroviruses, 1992, 8, 145, (pharmacol, rev)
  • Merluzzi, V.J. et al., Adv. Exp. Med. Biol., 1992, 312, 89, (rev)
  • Mui, P.W. et al., J. Med. Chem., 1992, 35, 201, (cryst struct)
  • Skoog, M.T. et al., Med. Res. Rev., 1992, 12, 27, (rev)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1393
  • Grozinger, K.G. et al., J. Het. Chem., 1995, 32, 259, (synth)
  • Pedersen, O.S. et al., Synthesis, 2000, 479-495, (rev)