Imiquimod

• Catalog No.: Bio-0788
• CAS Number: 99011-02-6
• M. F.: C14H16N4
• M. W.: 240.30364

SYNONYMS

• IUPAC name: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
• IUPAC Traditional name: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

DATABASE IDS

• CAS Number: 99011-02-6

PROPERTIES

• Application(s): Immunostimulant
• Application(s): Virucide
• Application(s): Cytostatic
• Mechanism of Action: Interferon inducer
• Mechanism of Action: Reported cell proliferation inducer

REFERENCES

• U.S. Pat., 1987, Riker, 4 689 338; CA, 108, 75403r, (synth, pharmacol)
• Chen, M. et al., Antimicrob. Agents Chemother., 1988, 32, 678, (pharmacol)
• Bernstein, D.I. et al., Antimicrob. Agents Chemother., 1989, 33, 1511, (pharmacol)
• Sidky, Y.A. et al., Cancer Res., 1992, 52, 3528, (activity)
• Bernstein, D.I. et al., Antiviral Res., 1993, 20, 45, (pharmacol)
• Witt, P.L. et al., Cancer Res., 1993, 53, 5176, (clin trial)
• Testerman, T.L. et al., J. Leukocyte Biol., 1995, 58, 365, (pharmacol)
• Yoshioka, H. et al., Chem. Pharm. Bull., 1996, 44, 709, (synth, pmr)
• Perry, C.M. et al., Drugs, 1999, 58, 375-390, (rev)
• Richwald, G.A. et al., Drugs of Today (Barcelona), 1999, 35, 497-511, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 613