Cyproheptadine

• Catalog No.: Bio-0780
• CAS Number: 129-03-3
• M. F.: C21H22ClN
• M. W.: 323.85908

SYNONYMS

• IUPAC name: 1-methyl-4-{tricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylidene}piperidine hydrochloride
• IUPAC Traditional name: 1-methyl-4-{tricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylidene}piperidine hydrochloride

DATABASE IDS

• CAS Number: 129-03-3

PROPERTIES

• Application(s): Antihistaminic and antiserotonergic agent
• Salt Data: HCl
• Mechanism of Action: Cyproheptadine competes with free histamine for binding at HA-receptor sites.
• Mechanism of Action: This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding

REFERENCES

• Engelhardt, E.L. et al., J. Med. Chem., 1965, 8, 829, (synth, pharmacol)
• Aboul-Enein, H.Y. et al., Anal. Profiles Drug Subst., 1980, 9, 155, (rev)
• Fischer, L.J. et al., Drug Metab. Dispos., 1980, 8, 422, (metab)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6064, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 935
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PCI250; PCI500