Fluphenazine

• Catalog No.: Bio-0775
• CAS Number: 69-23-8
• M. F.: C22H26F3N3OS
• M. W.: 437.5215496

SYNONYMS

• IUPAC name: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
• IUPAC Traditional name: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
• Synonyms: Flufenazine

DATABASE IDS

• CAS Number: 69-23-8

PROPERTIES

• Mechanism of Action: Dopamine-turnover stimulant in the forebrain
• Mechanism of Action: Postsynaptic dopamine-antagonist in: basal ganglia; hypothalamus; limbic-system; brain-stem; medulla
• Mechanism of Action: Mechanism of action not fully understood.
• Mechanism of Action: Calmodulin-antagonist
• Mechanism of Action: Dopamine-antagonist
• Mechanism of Action: Dopamine-release inhibitor
• Mechanism of Action: Increases neuronal firing-rate in the midbrain
• Application(s): Tranquilliser
• Application(s): Neuroleptic
• Application(s): Psychosedative

REFERENCES

• Yale, H.L. et al., J.A.C.S., 1960, 82, 2039, (synth)
• U.K. Pat., 1960, 829 246; CA, 54, 17428
• U.K. Pat., 1960, 833 473; CA, 54, 21143
• Ger. Pat., 1964, 1 165 602; CA, 60, 15886, (deriv)
• U.S. Pat., 1965, 3 194 733; CA, 64, 5114, (derivs)
• Gowda, H.S. et al., Rev. Roum. Chim., 1977, 22, 745; CA, 87, 126635a, (use)
• Curry, S.H. et al., Br. J. Clin. Pharmacol., 1979, 7, 325, (metab)
• Kreyenbuehl, B. et al., Pharm. Acta Helv., 1979, 54, 197, (uv, ir)
• Clarke, G., Anal. Profiles Drug Subst., 1980, 9, 275, (rev, decanoate)
• Shetty, H.U. et al., Biomed. Mass Spectrom., 1983, 10, 601, (ms)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6546; 7787; 7963, (synonyms)
• Phenothiazines and 1,4-Benzothiazines, (ed. Gupta, R.R.), Elsevier, Amsterdam, 1988, (book, pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 596
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FMP000; PMI250; TJW500