Flurbiprofen

• Catalog No.: Bio-0772
• CAS Number: 5104-49-4
• M. F.: C15H13FO2
• M. W.: 244.2609232

SYNONYMS

• IUPAC name: 2-(3-fluoro-4-phenylphenyl)propanoic acid
• IUPAC Traditional name: 2-(3-fluoro-4-phenylphenyl)propanoic acid
• Synonyms: Ocufen; Froben

DATABASE IDS

• CAS Number: 5104-49-4

PROPERTIES

• Application(s): Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.
• Application(s): Analgesic
• Application(s): Antipyretic
• Application(s): Mydriatic used in ocular surgery.
• Mechanism of Action: Carbonic Anhydrase Inhibitor
• Mechanism of Action: Cyclooxygenase Inhibitor
• Mechanism of Action: Prostaglandin antagonist

REFERENCES

• U.S. Pat., 1973, 3 755 427; CA, 79, 104952j, (synth, pharmacol)
• Adams, S.S. et al., Arzneim.-Forsch., 1975, 25, 1786, (pharmacol)
• Brogden, R.N. et al., Drugs, 1979, 18, 417, (rev, pharmacol)
• Maitre, J.M. et al., J. Chromatogr., 1984, 299, 397, (hplc)
• Dai, G. et al., CA, 1985, 102, 220521, (synth)
• Kulmacz, R.J. et al., J. Biol. Chem., 1985, 260, 12572, (pharmacol)
• Kantor, T.G., Am. J. Med., 1986, 80, 3, (rev)
• Kaiser, D.G. et al., Am. J. Med., 1986, 80, 10, (rev)
• U.S. Pat., 1986, 4 581 463; CA, 105, 78673c, (synth, isomer)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3469, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 16
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FLG100