Chlorprothixene

• Catalog No.: Bio-0770
• CAS Number: 113-59-7
• M. F.: C18H18ClNS
• M. W.: 315.86022

SYNONYMS

• IUPAC name: {3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
• IUPAC Traditional name: {3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
• Synonyms: Truxal; Tarasan; Chlothixen; Taractan; Traquilan

DATABASE IDS

• CAS Number: 113-59-7

PROPERTIES

• Application(s): Tranquilliser
• Application(s): Neuroleptic
• Application(s): Psychosedative
• Application(s): Antihistamine
• Mechanism of Action: Strong blocking effects at the following postsynaptic receptors:
• Mechanism of Action: 5-HT2 : anxiolysis, antipsychotic effects
• Mechanism of Action: D1, D2, D3 : antipsychotic effects
• Mechanism of Action: H1 : sedation, weight gain
• Mechanism of Action: Muscarinic : anticholinergic side effects, extrapyramidal side effects attenuated
• Mechanism of Action: Alpha1 : hypotension, tachycardia

REFERENCES

• U.K. Pat., 1960, 829 763; CA, 54, 24811, (synth)
• Biel, J.H., Princ. Psychopharmacol., Academic Press, New York, 1970, 269, (rev, pharmacol)
• Rudy, B.C. et al., Anal. Profiles Drug Subst., 1973, 2, 63, (rev)
• de Leenheer, A., J. Assoc. Off. Anal. Chem., 1973, 56, 105, (uv)
• Post, M.L. et al., Acta Cryst. B, 1974, 30, 1644, (cryst struct)
• Kaiser, C. et al., J. Med. Chem., 1974, 17, 131, (pmr)
• Irwin, W.J. et al., Chem. Br., 1982, 708, (hplc)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 4729, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 581
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TAF675