Sulfamonomethoxine

• Catalog No.: Bio-0762
• CAS Number: 1220-83-3
• M. F.: C11H12N4O3S
• M. W.: 280.30298

SYNONYMS

• IUPAC name: 4-amino-N-(6-methoxypyrimidin-4-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-(6-methoxypyrimidin-4-yl)benzene-1-sulfonamide
• Synonyms: Daimeton

DATABASE IDS

• CAS Number: 1220-83-3

PROPERTIES

• Application(s): Antibacterial agent (depot sulfonamide)
• Application(s): Antiseptic
• Mechanism of Action: Folate antagonist
• Mechanism of Action: Dihydrofolate reductase inhibitor
• Mechanism of Action: Dihydrofolate synthesis inhibitor

REFERENCES

• Clarkson, R. et al., Nature (London), 1961, 192, 523, (pharmacol)
• Rieder, J., Arzneim.-Forsch., 1963, 13, 81, (phys props, pharmacol)
• Tanaka, Y. et al., Chem. Pharm. Bull., 1965, 13, 399, (ir)
• Zasosov, V.A. et al., Khim.-Farm. Zh., 1974, 8, 28, (synth)
• Nose, N. et al., J. Chromatogr., 1976, 123, 167, (glc)
• Vree, T.B. et al., Drug Metab. Dispos., 1990, 18, 852, (pharmacokinet, metab, human)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 205
• Uno, K. et al., J. Chromatogr., B: Biomed. Appl., 1995, 663, 177, (hplc)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, SNL800