Succinylsulfathiazole

• Catalog No.: Bio-0761
• CAS Number: 116-43-8
• M. F.: C13H13N3O5S2
• M. W.: 355.38942

SYNONYMS

• IUPAC name: 3-({4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}carbamoyl)propanoic acid
• IUPAC Traditional name: 3-({4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}carbamoyl)propanoic acid
• Synonyms: Sulfasuxidine; Kaoxidin; Succinylsulphathiazole; Colistatin

DATABASE IDS

• CAS Number: 116-43-8

PROPERTIES

• Application(s): Intestinal antibacterial agent
• Application(s): Antiseptic
• Application(s): Antidiarrheic
• Mechanism of Action: Dihydrofolate reductase inhibitor
• Mechanism of Action: Folate antagonist
• Mechanism of Action: Dihydrofolate synthesis inhibitor

REFERENCES

• Poth, E.J. et al., Arch. Surg. (Chicago), 1942, 44, 187-222, (pharmacol)
• Moore, M.L. et al., J.A.C.S., 1942, 64, 1572-1576, (synth)
• U.S. Pat., 1944, Sharp and Dohme, 2 324 013; CA, 38, 2193, (synth)
• Phillips, M.A., Chem. Ind. (London), 1945, 247, (synth)
• Kram, T.C., J. Pharm. Sci., 1972, 61, 254, (hplc)
• Moustafa, M.A. et al., J. Pharm. Sci., 1974, 63, 1103-1109, (polymorph)
• Chang, C.J. et al., J. Med. Chem., 1975, 18, 505, (nmr)
• Rodier, N. et al., Acta Cryst. B, 1978, 34, 218-221, (cryst struct)
• Burger, A. et al., Sci. Pharm., 1989, 57, 293-305, (polymorph, struct, props)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 204
• Bourne, S.A. et al., J. Pharm. Sci., 1994, 83, 887-892, (cryst struct solvates)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3391