Carbamazepine

• Catalog No.: Bio-0751
• CAS Number: 298-46-4
• M. F.: C15H12N2O
• M. W.: 236.26858

SYNONYMS

• IUPAC name: 2-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide
• IUPAC Traditional name: 2-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide
• Synonyms: Carbium; Timonil; Teril; Epimaz; Prozine; Atretol; Carba; Carbagamma; Neurotop; Sirtal; Trimonil; Epitol; Tegretol

DATABASE IDS

• CAS Number: 298-46-4

PROPERTIES

• Application(s): Used to treat trigeminal neuralgia
• Application(s): Anticonvulsant
• Mechanism of Action: Apparent mode of action: posttetanic potentiation inhibitor
• Mechanism of Action: Exact mechanism unknown.
• Mechanism of Action: Reduces polysynaptic responses

REFERENCES

• Schmutz, M., Handb. Exp. Pharmacol., 1985, 74, 479, (Carbamazepine, rev)
• Al-Showaier, I. et al., J. Het. Chem., 1986, 23, 731, (ms)
• Fromm, G.H., Drugs Control Epilepsy, 1992, 425, (Carbamazepine, rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4398, (synonyms)
• Antiepileptic Drugs, (Eds., Levy, R.H. et al), 4th edn., Raven Press, 1995
• Tokmakov, G.P. et al., Tetrahedron, 1995, 51, 2091, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 339
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DCV200
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 681B, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1451A; 3, 164A, (nmr)
• Huisgen, R. et al., Chem. Ber., 1960, 93, 392, (synth)
• Bergmann, E.D. et al., J.O.C., 1960, 25, 827, (synth)
• Davis, M.A. et al., J. Med. Chem., 1964, 7, 88, (Carbamazepine)
• Aboul-Enein, H.Y. et al., Anal. Profiles Drug Subst., 1980, 9, 87, (rev, Carbamazepine)
• Himes, V.L. et al., Acta Cryst. B, 1981, 37, 2242, (Carbamazepine)
• Sinha, A.K. et al., Indian J. Chem., Sect. B, 1982, 21, 237, (synth, Carbamazepine)
• Harding, M.M., Acta Cryst. C, 1983, 39, 397, (cryst struct)
• Molock, F.F. et al., J. Het. Chem., 1983, 20, 109, (cmr)
• MacKichan, J.J., Appl. Ther. Drug Monit., 1984, 2, 73, (rev, anal, Carbamazepine)
• Hallberg, A. et al., J. Het. Chem., 1984, 21, 197, (pmr, cmr)