Oxatomide

• Catalog No.: Bio-0750
• CAS Number: 60607-34-3
• M. F.: C27H30N4O
• M. W.: 426.5533

SYNONYMS

• IUPAC name: 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
• IUPAC Traditional name: 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
• Synonyms: Cenacert; Tinset; Oxatimide; Truxa; Fensedyl

DATABASE IDS

• CAS Number: 60607-34-3

PROPERTIES

• Application(s): Antiasthmatic
• Application(s): Antihistamine agent
• Mechanism of Action: Histamine H 1 receptor antagonist
• Mechanism of Action: Also a mediator release inhibitor via Ca influx inhibition mechanism

REFERENCES

• Awouters, F. et al., Experientia, 1977, 33, 1657, (pharmacol, rev)
• Ger. Pat., 1977, Janssen, 2 714 437; CA, 88, 50920n, (synth, pharmacol)
• Richards, D.M. et al., Drugs, 1984, 27, 210, (rev, pharmacol)
• Meuldermans, W. et al., Xenobiotica, 1984, 14, 445, (metab)
• Gomez-Parra, V. et al., Monatsh. Chem., 1985, 116, 639, (synth)
• Raves, M.L. et al., Acta Cryst. C, 1992, 48, 1712, (cryst struct)
• Akamatsu, H. et al., Biol. Pharm. Bull., 1993, 16, 568, (pharmacol)
• Paulussen, J.J.C. et al., Arzneim.-Forsch., 1996, 46, 496, (pharmacol, sar)
• Paulussen, J.J.C. et al., Eur. J. Pharmacol., 1996, 312, 121, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 448