Cinnarizine

• Catalog No.: Bio-0747
• CAS Number: 298-57-7
• M. F.: C26H28N2
• M. W.: 368.51392

SYNONYMS

• IUPAC name: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
• IUPAC Traditional name: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
• Synonyms: Aplactan; Stugeron; Mitronal

DATABASE IDS

• CAS Number: 298-57-7

PROPERTIES

• Application(s): Cerebral blood flow improver used for treatment of apoplexy and arteriosclerosis
• Mechanism of Action: Histamine H 1 receptor antagonist
• Mechanism of Action: Calcium antagonist
• Mechanism of Action: Reported catecholamine depletor
• Mechanism of Action: Reported Proton pump uncoupler
• Mechanism of Action: Reported to inhibit cardiac liposomal lipid peroxidation mediated by the xanthine oxidase system
• Mechanism of Action: Reported inhibitor of bioenergetics of chromaffin granule ghosts
• Mechanism of Action: Reported Mg-atpase inhibitor

REFERENCES

• Belg. Pat., 1960, 556 791; CA, 1960, 54, 590
• U.K. Pat., 1960, 809 760; CA, 1960, 54, 2379, (synth)
• Cotrait, M. et al., Acta Cryst. B, 1975, 31, 1495, (cryst struct)
• Towse, G., Int. Congr. Symp. Ser. R. Soc. Med., (Ed.), 1980, 33, (book)
• Gotfraind, T. et al., Drugs of Today (Barcelona), 1982, 18, 27, (rev, pharmacol)
• Spedding, M., Naunyn-Schmiedeberg's Arch. Pharmacol., 1982, 318, 234, (pharmacol)
• Yao, F. et al., CA, 1984, 101, 211103, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7401, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 934
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CMR100; CMS125