Pentoxifylline

• Catalog No.: Bio-0744
• CAS Number: 6493-05-6
• M. F.: C13H18N4O3
• M. W.: 278.30702

SYNONYMS

• IUPAC name: 3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• Synonyms: Azupentat; Pentoflux; Agapurin; Vazofirin; Torental

DATABASE IDS

• CAS Number: 6493-05-6

PROPERTIES

• Application(s): It is used to treat intermittent claudication resulting from obstructed arteries in the limbs, and vascular dementia
• Application(s): Pentoxifylline improves blood flow through blood vessels and therefore helps with blood circulation in the arms and legs (e.g. intermittent claudication)
• Application(s): It also helps prevent strokes, can be used in managing sickle cell disease and improves blood flow to the brain
• Application(s): Pentoxifylline has also been used to treat nausea and headaches in the mountains (altitude sickness).
• Mechanism of Action: Inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity
• Mechanism of Action: Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity

REFERENCES

• Mohler, W. et al., Arzneim.-Forsch., 1971, 21, 1159, (synth, props)
• Popendiker, K. et al., Arzneim.-Forsch., 1971, 21, 1160; 1171, (pharmacol)
• Hinze, H.J., Arzneim.-Forsch., 1971, 21, 1456, (uv, ir, pmr, ms)
• Mueller, R. et al., Curr. Med. Res. Opin., 1981, 7, 253, (rev)
• Conde, L.A., Khim.-Farm. Zh., 1986, 20, 493, (rev, pharmacol)
• Cadis, E. et al., Rev. Chim. (Bucharest), 1986, 37, 335, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3582, (synonyms)
• Indrayanto, G. et al., Anal. Profiles Drug Subst., 1998, 25, 295-339, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 925
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PBU100