Flunarizine

• Catalog No.: Bio-0741
• CAS Number: 52468-60-7
• M. F.: C26H26F2N2
• M. W.: 404.4948464

SYNONYMS

• IUPAC name: 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
• IUPAC Traditional name: 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
• Synonyms: 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine; 4',4''-Difluorocinnarizine

DATABASE IDS

• CAS Number: 52468-60-7

PROPERTIES

• Application(s): Effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
• Application(s): It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
• Mechanism of Action: Calcium channel blocker
• Mechanism of Action: Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity

REFERENCES

• Ger. Pat., 1972, 2 220 242; CA, 78, 29815r, (synth)
• Amery, W.K. et al., Drugs Exp. Clin. Res., 1981, 7, 1, (pharmacol)
• Marini, D. et al., Boll. Chim. Farm., 1984, 123, 133, (struct, uv, ir)
• Holmes, B. et al., Drugs, 1984, 29, 6, (rev, pharmacol)
• Xiang, M. et al., CA, 1985, 102, 78835, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7382, (synonyms)
• Schmidt, R. et al., J. Cardiovasc. Pharmacol., (Suppl. 8), 1991, 18, S27, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 939
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FDD080