Famotidine

• Catalog No.: Bio-0739
• CAS Number: 76824-35-6
• M. F.: C8H15N7O2S3
• M. W.: 337.4454

SYNONYMS

• IUPAC name: (Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
• IUPAC Traditional name: (Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
• Synonyms: Pepdine; Pepdul; Famodil; Gaster; Amifatidine; Ganor; Gastridin; Motiax; Pepcid; Pepcidac; Pepcidine

DATABASE IDS

• CAS Number: 76824-35-6

PROPERTIES

• Application(s): Used in treatment of gastric and duodenal ulcers, gastro-oesophageal reflux disease and Zollinger-Ellison syndrome.
• Application(s): Suggested beneficial effect in treatment of schizophrenia.
• Application(s): Antiviral agent
• Mechanism of Action: Histamine H 2 receptor antagonist
• Mechanism of Action: Gastric secretion inhibitor
• Mechanism of Action: Weak pepsin inhibitor

REFERENCES

• Ger. Pat., 1980, Yamanouchi, 3 008 056; CA, 94, 156916e, (synth, pharmacol)
• Takagi, T. et al., Arch. Int. Pharmacodyn. Ther., 1982, 256, 49, (pharmacol)
• Golic, L. et al., Acta Cryst. C, 1989, 45, 1381, (cryst struct)
• Langtry, H.D. et al., Drugs, 1989, 38, 551, (rev)
• J. Int. Med. Res., Suppl. 1, 1989, 17, 1A, (rev)
• Wanwimolruk, S. et al., J. Chromatogr., 1991, 572, 227, (hplc)
• Imai, Y. et al., Biomed. Chromatogr., 1992, 6, 222, (hplc)
• Katsura, Y. et al., Chem. Pharm. Bull., 1992, 40, 2432, (analogues, activity)
• Oyewumi, L.K. et al., J. Psychiatry Neurosci., 1994, 19, 145; 20, 239, (use)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 1216, (synonyms)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1192
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FAB500