Anisindione

• Catalog No.: Bio-0735
• CAS Number: 117-37-3
• M. F.: C16H12O3
• M. W.: 252.26468

SYNONYMS

• IUPAC name: 2-(4-methoxyphenyl)-2,3-dihydro-1H-indene-1,3-dione
• IUPAC Traditional name: 2-(4-methoxyphenyl)-2,3-dihydro-1H-indene-1,3-dione
• Synonyms: 2- p -Anisyl-1,3-indanedione; Miradon

DATABASE IDS

• CAS Number: 117-37-3

PROPERTIES

• Application(s): Orally active anticoagulant
• Description: Tautomers
• Mechanism of Action: Interferes with synthesis of vitamin-K-dependent
• Mechanism of Action: Clotting-factors
• Mechanism of Action: Depletes clotting-factor-VII
• Mechanism of Action: Depletes clotting-factor-IX
• Mechanism of Action: Depletes clotting-factor-X
• Mechanism of Action: Depletes prothrombin

REFERENCES

• Horeau, A. et al., Bull. Soc. Chim. Fr., 1948, 53
• Molho, D. et al., C. R. Hebd. Seances Acad. Sci., 1961, 252, 336, (pharmacol)
• Perjessy, A. et al., Tetrahedron, 1971, 27, 6154, (nmr)
• Pisarenko, L.M. et al., Dokl. Akad. Nauk SSSR, 1973, 213, 638, (nmr)
• Nauta, W.Th. et al., Pharmacochemistry of 1,3-Indandiones, Elsevier, Amsterdam, 1981, 187, (pharmacol, rev)
• Murthy, A.R. et al., J. Med. Chem., 1985, 28, 1591, (synth)
• Grosset, A.B.M. et al., Am. J. Hematol., 1994, 46, 138, (use)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 825