LY-290181

• Catalog No.: Bio-0725
• CAS Number: 149550-36-7
• M. F.: C20H13N3O3
• M. W.: 343.33552

SYNONYMS

• IUPAC name: 2-amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile
• IUPAC Traditional name: 2-amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile

DATABASE IDS

• CAS Number: 149550-36-7

PROPERTIES

• Application(s): Antiproliferative
• Application(s): Antimitotic
• Application(s): Antiarteriosclerotic
• Mechanism of Action: Metalloproteinase inhibitor
• Mechanism of Action: Protein kinase C inhibitor
• Mechanism of Action: Myocyte proliferation inhibitor

REFERENCES

• 1. S. Chandrasekhar, A. K. Harvey, C. P. Dell, S. J. Ambler, C. W. Smith Identification of a Novel Chemical Series that Blocks Interleukin-1-Stimulated Metalloprotease Activity in Chondrocytes
• Journal of Pharmacology and Experimental Therapeutics 273(3): 1519-1528, 1995
• 2. D. L. Wood, D. Panda, T. R. Wiernicki, L. Wilson, M. A. Jordan, J. P.
• Singh nhibition of Mitosis and Microtubule Function through Direct Tubulin Binding by a Novel Antiproliferative Naphthopyran LY290181 Mol. Pharmacol. September 1, 1997 52:437-444
• 3. Birch K. A., Heath W. F., Hermling R. N., Johnston C. M., Stramm L., Dell C., Smith C., Williamson J. R., Miller A. R. (1996)
• LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcription factor binding to phorbol response element. Diabetes 45:642?50.