Hydrochlorothiazide

• Catalog No.: Bio-0714
• CAS Number: 58-93-5
• M. F.: C7H8ClN3O4S2
• M. W.: 297.73912

SYNONYMS

• IUPAC name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ^6,2,4-benzothiadiazine-7-sulfonamide
• IUPAC Traditional name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ^6,2,4-benzothiadiazine-7-sulfonamide
• Synonyms: Vetidrex; Esidrex

DATABASE IDS

• CAS Number: 58-93-5

PROPERTIES

• Application(s): Diuretic and antihypertensive agent
• Application(s): Chloruretic
• Application(s): Kaliuretic.
• Application(s): Natriuretic
• Mechanism of Action: Carbonic anhydrase inhibitor

REFERENCES

• de Stevens, G. et al., Experientia, 1958, 14, 463
• Swiss Pat., 1959, Ciba, 337 203; CA, 54, 21147i, (synth, pharmacol)
• Close, W.J. et al., J.A.C.S., 1960, 82, 1132, (synth)
• Werner, L.H. et al., J.A.C.S., 1960, 93, 1161, (synth, pharmacol)
• Klosa, J. et al., J. Prakt. Chem., 1962, 16, 264, (synth)
• Dupont, L. et al., Acta Cryst. B, 1972, 28, 2340, (cryst struct)
• Beermann, B. et al., Clin. Pharmacol. Ther. (St. Louis), 1976, 19, 531, (metab)
• Deppeler, H.P., Anal. Profiles Drug Subst., 1981, 10, 405, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 681, (synonyms)
• IARC Monog., 1990, 50, 293, (rev, tox)
• Danielsen-Runge, W., Dtsch. Apoth. -Ztg., 1992, 132, 1950, (rev)
• Kountourellis, J.E. et al., J. Chem. Eng. Data, 1992, 37, 187, (cryst struct)
• Diuretics IV: Proc. Int. Conf. Diuretics, 4th, 1992, (eds. Puschett, J.B. et al), Excerpta Medica, Amsterdam, 1993, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 818
• Gottdiener, J.S. et al., Circulation, 1997, 95, 2007, (use)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CFY000