Tegafur

• Catalog No.: Bio-0706
• CAS Number: 17902-23-7
• M. F.: C8H9FN2O3
• M. W.: 200.1670632

SYNONYMS

• IUPAC name: 5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: 5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
• Synonyms: Furflucil; Ftorafur; Neberk; Sinoflurol; Futraful; Citofur

DATABASE IDS

• CAS Number: 17902-23-7

PROPERTIES

• Application(s): Antineoplastic agent
• Application(s): Cytostatic
• Mechanism of Action: Thymidylate synthetase inhibitor
• Mechanism of Action: DNA synthesis inhibitor
• Mechanism of Action: RNA synthesis inhibitor
• Mechanism of Action: Fluorouracil prodrug

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 366A, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 811D, (ir)
• Yasumoto, M. et al., J. Med. Chem., 1977, 20, 1592, (synth, resoln)
• Loo, T.L. et al., Drug Metab. Rev., 1978, 8, 137, (metab, rev)
• Yamamoto, S. et al., Arzneim.-Forsch., 1981, 31, 1268, (pharmacol)
• Au, J. et al., Cancer Chemother. Pharmacol., 1981, 7, 55, (metab)
• Nakai, Y. et al., Chem. Pharm. Bull., 1982, 30, 2629; 1986, 34, 1242, (cryst struct, bibl)
• Fujimoto, S., Drugs of Today (Barcelona), 1985, 21, 125, (rev, pharmacol)
• Ozaki, S. et al., Chem. Pharm. Bull., 1986, 34, 150, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 878
• Uchida, T. et al., Chem. Pharm. Bull., 1993, 41, 1632, (polymorphism)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 502
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FMB000; UNJ810