Nicorandil

• Catalog No.: Bio-0696
• CAS Number: 65141-46-0
• M. F.: C8H9N3O4
• M. W.: 211.17476

SYNONYMS

• IUPAC name: 2-(pyridin-3-ylformamido)ethyl nitrate
• IUPAC Traditional name: 2-(pyridin-3-ylformamido)ethyl nitrate
• Synonyms: Perisalol; Siomart; N -(2-Hydroxyethyl)nicotinamide nitrate; N -[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide; Sigmart; Ikorel

DATABASE IDS

• CAS Number: 65141-46-0

PROPERTIES

• Application(s): Antioxidant
• Application(s): Cardiant
• Application(s): Smooth muscle relaxant
• Mechanism of Action: Guanylate cyclase stimulator
• Mechanism of Action: Potassium channel activator
• Mechanism of Action: Reported vasodilador
• Mechanism of Action: Reported potassium agonist
• Mechanism of Action: Reported deoxyribose breakdown inhibitor
• Mechanism of Action: May act as an indirect calcium antagonist
• Mechanism of Action: Antioxidant

REFERENCES

• Ger. Pat., 1977, Chugai Pharm, 2 714 713; CA, 88, 22652, (synth, pharmacol)
• Taira, N. et al., Clin. Exp. Pharmacol. Physiol., 1979, 6, 301, (pharmacol)
• Frydman, A.M. et al., Am. J. Cardiol., 1989, 63, 25J, (pharmacokinet)
• Frampton, J. et al., Drugs, 1992, 44, 625, (rev)
• Purcell, H. et al., Br. J. Clin. Pract., 1993, 47, 150, (rev)
• Kato, K. et al., Eur. Heart J., Suppl. B, 1993, 14, (rev)
• Tanikawa, M. et al., J. Chromatogr., 1993, 617, 163, (hplc)
• Bachert, E.L. et al., J. Chromatogr., 1993, 619, 336, (hplc)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1025
• Matsui, T. et al., Acta Neurochir. (Vienna), 1994, 126, 165, (pharmacol)
• Jaraki, O. et al., J. Cardiovasc. Pharmacol., 1994, 23, 24, (pharmacol)
• Naito, A. et al., Jpn. J. Pharmacol., 1994, 65, 209, (pharmacol)
• Markham, A. et al., Drugs, 2000, 60, 955-974, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, NDL800