Didanosine

• Catalog No.: Bio-0685
• CAS Number: 69655-05-6
• M. F.: C10H12N4O3
• M. W.: 236.22728

SYNONYMS

• IUPAC name: 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
• IUPAC Traditional name: 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
• Synonyms: Videx; 2',3'-Dideoxy-1,9-dihydro-9-beta- D -ribofuranosyl-6 H -purin-6-one; 2',3'-Dideoxyinosine

DATABASE IDS

• CAS Number: 69655-05-6

PROPERTIES

• Application(s): Antiviral agent
• Application(s): Potentially of use against HIV infection and used in combination with other antiretroviral drug therapy as part of highly active
• Application(s): Nucleoside transporter substrate.
• Mechanism of Action: Reverse Transcriptase inhibitor
• Mechanism of Action: Cell proliferation inhibitor

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 215B, (nmr)
• Mitsuya, H. et al., Proc. Natl. Acad. Sci. U.S.A., 1986, 83, 1911, (pharmacol)
• Ray, G. et al., Anal. Lett., 1987, 20, 1815, (hplc)
• Ahluwalia, G. et al., Biochem. Pharmacol., 1987, 36, 3797
• Hao, Z. et al., Mol. Pharmacol., 1988, 34, 431, (pharmacol)
• Chu, C.K. et al., J.O.C., 1989, 54, 2217, (synth, pmr)
• McGowan, J.J. et al., Rev. Infect. Dis., 1990, 12, S513, (rev, antiretroviral props)
• Shelton, M.J. et al., Ann. Pharmacother., 1992, 26, 660, (rev)
• Wu, X. et al., J. Biol. Chem., 1992, 267, 8813-8818, (pharmacol)
• Bhat, V. et al., Synth. Commun., 1992, 22, 1481, (synth, pmr, uv)
• Nassar, M.N. et al., Anal. Profiles Drug Subst., 1993, 22, 185, (rev)