Testosterone

• Catalog No.: Bio-0678
• CAS Number: 58-22-0
• M. F.: C19H28O2
• M. W.: 288.42442

SYNONYMS

• IUPAC name: (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• IUPAC Traditional name: (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• Synonyms: Andropatch; Atmos

DATABASE IDS

• CAS Number: 58-22-0

PROPERTIES

• Application(s): Used in the treatment of male hypogonadism (transdermal administration)
• Biological Source: Constit. of human urine
• Mechanism of Action: Androgen
• Mechanism of Action: FSH antagonist.
• Mechanism of Action: ICSH antagonist
• Mechanism of Action: The steroid receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action
• Mechanism of Action: High dose: spermatogenesis inhibitor
• Mechanism of Action: Exogenous administration inhibits endogenous release via feedback inhibition of pituitary ICSH
• Mechanism of Action: Activity in many tissues appears to depend on reduction to dihydrotestosterone which binds to cytosolic receptor proteins
• Mechanism of Action: Gonadotropin antagonist

REFERENCES

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