Desoxycortone

• Catalog No.: Bio-0673
• CAS Number: 64-85-7
• M. F.: C21H30O3
• M. W.: 330.4611

SYNONYMS

• IUPAC name: (1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• IUPAC Traditional name: (1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• Synonyms: Cortexon;Corticormon; Corthormon; Cortexone; Kendall's desoxy compound B; Ocriten; Deoxycortone; Reichstein's Substance Q; Decortene; Ormosurrenol

DATABASE IDS

• CAS Number: 64-85-7

PROPERTIES

• Application(s): Mineralocorticoid
• Biological Source: Obt. by incubation of 9b,10a-pregn-4-ene-3,20-dione with Curvularia spp.
• Mechanism of Action: ACTH secretion inhibitor
• Mechanism of Action: Gluconeogenesis promoter
• Mechanism of Action: Glycogen deposition inhibitor

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 583C; 602C, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1054B, (ir)
• Reichstein, T. et al., Helv. Chim. Acta, 1937, 20, 1164; 1938, 21, 1197, (isol)
• Schindler, W. et al., Helv. Chim. Acta, 1941, 24, 371, (synth)
• Zaffaroni, A. et al., Experientia, 1955, 11, 219, (synth)
• U.S. Pat., 1966, 3 254 098; CA, 65, 8999, (synth)
• Grostic, M.F. et al., J.O.C., 1968, 33, 1740, (ms)
• van der Sijde, D. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1969, 88, 1437, (synth)
• Schambelan, M. et al., J. Clin. Endocrinol. Metab., 1972, 34, 695, (metab)
• Dideberg, O. et al., Acta Cryst. B, 1973, 29, 103, (cryst struct)
• Gonzalez, M.D. et al., Org. Magn. Reson., 1984, 22, 586, (cmr)
• Numazawa, M. et al., J.O.C., 1985, 50, 81, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6984, (synonyms)
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 727
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DAQ600; DAQ800