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Cortisone

Catalog No. Bio-0664 Name InterBioScreen
CAS Number 53-06-5 Website http://www.ibscreen.com
M. F. C21H28O5 Telephone +7 49652 40091
M. W. 360.44402 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 105422

SYNONYMS

IUPAC name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-ene-5,17-dione
IUPAC Traditional name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-ene-5,17-dione
Synonyms
17-Hydroxy-11-dehydrocorticosterone
Reichstein's Substance Fa
Wintersteiner's compound F
Kendall's compound E

DATABASE IDS

CAS Number 53-06-5

PROPERTIES

Application(s) Used in rheumatoid arthritis and rheumatic fever therapy
Application(s) Antiinflammatory agent
Application(s) Immunosuppressive
Biological Source Adrenal cortical hormone
Mechanism of Action Corticosteroid
Mechanism of Action ACTH secretion inhibitor
Mechanism of Action Gluconeogenesis promoter
Mechanism of Action Glycogen deposition inhibitor
Mechanism of Action Calcium mobilizer
Mechanism of Action Phosphorus mobilizer

DETAILS

REFERENCES

  • drich Library of 13C and 1H FT NMR Spectra, 1992, 3, 587A; 602B, (nmr)
  • Reichstein, T., Helv. Chim. Acta, 1936, 19, 1107; 1937, 20, 978, (isol, Cortisone)
  • Sarett, L.H., J.A.C.S., 1948, 70, 1454, (synth)
  • Rosenkranz, G. et al., J.A.C.S., 1951, 73, 4055, (synth)
  • Woodward, R.B. et al., J.A.C.S., 1951, 73, 4057, (synth)
  • Sarett, L.H. et al., J.A.C.S., 1952, 74, 4974, (synth)
  • Hayden, A.L., Anal. Chem., 1955, 27, 1486, (ir, Cortisone)
  • Green, G.F.H. et al., J.C.S., 1965, 7328, (pmr, Cortisone)
  • Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731
  • Saucy, G. et al., Helv. Chim. Acta, 1967, 50, 1394, (synth, uv, ir, pmr, 10-form)
  • Genard, P. et al., Steroids, 1968, 12, 763, (ms, Cortisone)
  • Weeks, C.M. et al., J.A.C.S., 1973, 95, 2865, (struct)
  • Hazen, G.G., J. Chem. Educ., 1980, 57, 291, (synth)
  • Horiguchi, Y. et al., J.O.C., 1986, 51, 4323, (synth)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6296; 6940, (synonyms)
  • Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 727
  • Muhtadi, F.J., Anal. Profiles Drug Subst., 1999, 26, 167-246, (rev)
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CNS800; CNS825