Roxithromycin

• Catalog No.: Bio-0657
• CAS Number: 80214-83-1
• M. F.: C41H76N2O15
• M. W.: 837.04654

SYNONYMS

• IUPAC name: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one
• IUPAC Traditional name: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one
• Synonyms: Antibiotic RU 28965; Abbotic; Cirumycin; Azuril; Macrosil; Roxitrol; Rulide; Rotramin

DATABASE IDS

• CAS Number: 80214-83-1

PROPERTIES

• Application(s): Immunomodulator
• Application(s): Antibiotic
• Application(s): Shows a similar range of antibacterial activity to Erythromycin BDQ81-E but is much more active in vivo
• Mechanism of Action: Protein synthesis inhibitor
• Mechanism of Action: Binds to the 50S subunit of ribosome

REFERENCES

• Fr. Pat., 1981, Roussel, 2 473 525; CA, 96, 123219, (synth)
• Jones, R.N. et al., Antimicrob. Agents Chemother., 1983, 24, 209, (props)
• Barlam, T. et al., Antimicrob. Agents Chemother., 1984, 25, 529, (props)
• Chantot, J.-F. et al., J. Antibiot., 1986, 39, 661, (props)
• Young, R.A. et al., Drugs, 1987, 37, 8, (rev, pharmacol)
• Phillips, I. et al., J. Antimicrob. Chemother., Suppl. B, (Eds.), 1987, 20, (book)
• Gharbi-Benarous, J. et al., Magn. Reson. Chem., 1990, 28, 846, (pmr, cmr, conformn)
• Gharbi-Benarous, J. et al., J. Med. Chem., 1991, 34, 1117, (pmr, cmr, conformn)
• Peruche, B. et al., Pharm. Ztg., 1992, 137, 32; 34; 36; 38; 40, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 201
• Markham, A. et al., Drugs, 1994, 48, 297, (rev)
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• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 11688, (synonyms)
• Infection (Munich), Suppl. 1, 1995, 23, (rev)