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Acarbose

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CAS Number 56180-94-0 Website http://www.ibscreen.com
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SYNONYMS

IUPAC name
(3R,4R,6R)-5-{[(3R,4R,6R)-5-{[(3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2,3,4-triol
IUPAC Traditional name
(3R,4R,6R)-5-{[(3R,4R,6R)-5-{[(3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2,3,4-triol
Synonyms
Precose
Glucobay
Amylostatin J
Prandase

DATABASE IDS

CAS Number 56180-94-0

PROPERTIES

Application(s) Used for treatment of diabetes, hyperlipidaemia and obesity
Biological Source Isol. from Actinoplanes sp.
Mechanism of Action A potent inhibitor of alpha-glucosidases and saccharases

DETAILS

REFERENCES

  • Ger. Pat., 1975, 2 347 782; CA, 83, 56721s
  • Schmidt, D.D. et al., Naturwissenschaften, 1977, 64, 535-536; 536-537, (isol, props)
  • Truscheit, E. et al., Angew. Chem., Int. Ed., 1981, 20, 744-761, (rev)
  • Creutzfeldt, W., Int. Congr. Ser. Excerpta Med., 1982, 594, (book)
  • Junge, B. et al., Carbohydr. Res., 1984, 128, 235-268, (struct)
  • Bock, K. et al., Carbohydr. Res., 1984, 132, 142-149, (conformn)
  • Ogawa, S. et al., Chem. Comm., 1988, 605, (synth)
  • Clissold, S.P. et al., Drugs, 1988, 35, 214, (rev, pharmacol)
  • Maul, W. et al., Arzneim.-Forsch., 1989, 39, 1251-1253, (synth)
  • Shibata, Y. et al., Carbohydr. Res., 1989, 189, 309-322, (synth)
  • Peruche, B., Pharm. Ztg., 1992, 137, 30; 32; 34; 36, (rev)