Hydrocortisone

• Catalog No.: Bio-0648
• CAS Number: 50-23-7
• M. F.: C21H30O5
• M. W.: 362.4599

SYNONYMS

• IUPAC name: (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• IUPAC Traditional name: (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• Synonyms: Hydrocortal; Cortisol;11beta,17alpha,21-Trihydroxyprogesterone; Reichstein's Substance M;Cortef; Hytone; Kendall's compound F; Cortenema; Efcortelan;Ficortril; Hydrocortone

DATABASE IDS

• CAS Number: 50-23-7

PROPERTIES

• Application(s): Topical antiinflammatory agent
• Application(s): Antiallergic
• Application(s): Immunosuppressive
• Biological Source: Adrenal cortical hormone
• Mechanism of Action: Glucocorticoid
• Mechanism of Action: ACTH secretion inhibitor
• Mechanism of Action: Phosphorus mobilizer
• Mechanism of Action: Gluconeogenesis promoter
• Mechanism of Action: Glycogen deposition inhibitor
• Mechanism of Action: Calcium mobilizer

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 584C, (nmr)
• Reichstein, T., Helv. Chim. Acta, 1937, 20, 953, (isol)
• v. Euw, J. et al., Helv. Chim. Acta, 1942, 25, 988, (struct)
• Zaffaroni, A. et al., J.A.C.S., 1951, 73, 1390, (biosynth)
• Shirasaka, M., Chem. Pharm. Bull., 1961, 9, 152, (synth)
• Saucy, G. et al., Helv. Chim. Acta, 1966, 49, 1529; 1967, 50, 1394, (synth, ir, uv, pmr)
• van der Sijde, D. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 721, (synth)
• Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731, (synth, struct, pmr)
• Bhacca, N.S. et al., J.A.C.S., 1973, 95, 8421, (cmr)
• Haskins, N.J. et al., Biomed. Mass Spectrom., 1974, 1, 423, (ms)
• Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (use)
• Genard, P., Org. Mass Spectrom., 1979, 12, 396, (pmr)
• Castellano, E.E. et al., Acta Cryst. B, 1980, 36, 3063, (cryst. struct)
• Florey, K., Anal. Profiles Drug Subst., 1983, 12, 277, (rev, synth, pharmacol, anal)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6346; 6986; 7335
• Minagawa, K. et al., J.C.S. Perkin 1, 1988, 587, (synth)
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 734
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BAV275; HHR000; CNS750; HHQ800; HHQ825; HHQ850; HHQ875