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Hydrocortisone

Catalog No. Bio-0648 Name InterBioScreen
CAS Number 50-23-7 Website http://www.ibscreen.com
M. F. C21H30O5 Telephone +7 49652 40091
M. W. 362.4599 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 621

SYNONYMS

IUPAC name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
IUPAC Traditional name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
Synonyms
Hydrocortal
Cortisol;11beta,17alpha,21-Trihydroxyprogesterone
Reichstein's Substance M;Cortef
Hytone
Kendall's compound F
Cortenema
Efcortelan;Ficortril
Hydrocortone

DATABASE IDS

CAS Number 50-23-7

PROPERTIES

Application(s) Topical antiinflammatory agent
Application(s) Antiallergic
Application(s) Immunosuppressive
Biological Source Adrenal cortical hormone
Mechanism of Action Glucocorticoid
Mechanism of Action ACTH secretion inhibitor
Mechanism of Action Phosphorus mobilizer
Mechanism of Action Gluconeogenesis promoter
Mechanism of Action Glycogen deposition inhibitor
Mechanism of Action Calcium mobilizer

DETAILS

REFERENCES

  • Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 584C, (nmr)
  • Reichstein, T., Helv. Chim. Acta, 1937, 20, 953, (isol)
  • v. Euw, J. et al., Helv. Chim. Acta, 1942, 25, 988, (struct)
  • Zaffaroni, A. et al., J.A.C.S., 1951, 73, 1390, (biosynth)
  • Shirasaka, M., Chem. Pharm. Bull., 1961, 9, 152, (synth)
  • Saucy, G. et al., Helv. Chim. Acta, 1966, 49, 1529; 1967, 50, 1394, (synth, ir, uv, pmr)
  • van der Sijde, D. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 721, (synth)
  • Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731, (synth, struct, pmr)
  • Bhacca, N.S. et al., J.A.C.S., 1973, 95, 8421, (cmr)
  • Haskins, N.J. et al., Biomed. Mass Spectrom., 1974, 1, 423, (ms)
  • Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (use)
  • Genard, P., Org. Mass Spectrom., 1979, 12, 396, (pmr)
  • Castellano, E.E. et al., Acta Cryst. B, 1980, 36, 3063, (cryst. struct)
  • Florey, K., Anal. Profiles Drug Subst., 1983, 12, 277, (rev, synth, pharmacol, anal)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6346; 6986; 7335
  • Minagawa, K. et al., J.C.S. Perkin 1, 1988, 587, (synth)
  • Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 734
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BAV275; HHR000; CNS750; HHQ800; HHQ825; HHQ850; HHQ875