Isosorbide

• Catalog No.: Bio-0643
• CAS Number: 652-67-5
• M. F.: C6H10O4
• M. W.: 146.1412

SYNONYMS

• IUPAC name: (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
• IUPAC Traditional name: (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
• Synonyms: Ismotic; Isobide. Isorgen G; Sorbide (obsol.); Devicoran; Hydronol

DATABASE IDS

• CAS Number: 652-67-5

PROPERTIES

• Application(s): Hypotensive
• Application(s): Diuretic
• Biological Source: Isol. from the fruit of Cotoneaster microphylla
• Mechanism of Action: Guanylate cyclase stimulator

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 406C, (nmr)
• Hockett, R.C. et al., J.A.C.S., 1946, 68, 927
• Wiggins, L.F., Adv. Carbohydr. Chem., 1950, 5, 191, (rev, props)
• Cope, A.C. et al., J.A.C.S., 1956, 78, 3177, (stereochem)
• Hopton, F.J. et al., Can. J. Chem., 1969, 47, 2395, (pmr)
• Soltzberg, S., Adv. Carbohydr. Chem. Biochem., 1970, 25, 229, (rev)
• Silvieri, L.A. et al., Anal. Profiles Drug Subst., 1975, 4, 225, (deriv)
• Hirao, A. et al., J.O.C., 1979, 44, 1720, (use)
• van Koningsveld, H. et al., Acta Cryst. C, 1984, 40, 519, (cryst struct)
• Bock, K. et al., Acta Chem. Scand., 1989, 43, 264, (L-form)
• Defraye, J. et al., Carbohydr. Res., 1990, 205, 191, (synth)
• Stoss, P. et al., Adv. Carbohydr. Chem. Biochem., 1991, 49, 93, (rev)
• Chandrasekaran, S. et al., Synthesis, 1994, 1032, (nitrates, synth)
• Duclos, A. et al., Synthesis, 1994, 1087, (synth, cmr)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CCK125; HID350; ISC500