Pindolol

• Catalog No.: Bio-0642
• CAS Number: 13523-86-9
• M. F.: C14H20N2O2
• M. W.: 248.3208

SYNONYMS

• IUPAC name: [2-hydroxy-3-(1H-indol-4-yloxy)propyl](propan-2-yl)amine
• IUPAC Traditional name: [2-hydroxy-3-(1H-indol-4-yloxy)propyl](propan-2-yl)amine
• Synonyms: Visken; Prindolol

DATABASE IDS

• CAS Number: 13523-86-9

PROPERTIES

• Application(s): Vasodilator
• Application(s): Used in treatment of Angina pectoris and hypertension
• Mechanism of Action: Non-cardioselective beta-Adrenoceptor antagonist
• Mechanism of Action: 5HT1A serotonin receptor antagonist
• Mechanism of Action: Possesses intrinsic sympathomimetic actions (ISA), but little membrane-stabilizing activity
• Mechanism of Action: Partial agonist
• Mechanism of Action: Sympatholytic-Beta
• Mechanism of Action: Vasodilator

REFERENCES

• Giudicelli, J.F. et al., J. Pharmacol. Exp. Ther., 1969, 168, 116, (pharmacol)
• Rivier, J.-L. et al., Therapie, 1970, 25, 245, (pharmacol)
• Seemann, F. et al., Helv. Chim. Acta, 1971, 54, 2411, (synth)
• Kuhnert-Brandstaetter, M. et al., Sci. Pharm., 1974, 42, 234, (uv)
• Tsuda, Y. et al., Chem. Pharm. Bull., 1981, 29, 3593, (synth)
• Aellig, W.H., Am. Heart J., 1982, 104, 333, (rev, pharmacol)
• Frishman, W.H., N. Engl. J. Med., 1983, 308, 904, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3266, (synonyms)
• Fuji, M. et al., Chem. Pharm. Bull., 1992, 40, 2353, (synth, pmr, ms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 637
• Ishibashi, H. et al., Chem. Pharm. Bull., 1994, 42, 271, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VSA000