Colchicine

• Catalog No.: Bio-0634
• CAS Number: 64-86-8
• M. F.: C22H25NO6
• M. W.: 399.437

SYNONYMS

• IUPAC name: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• IUPAC Traditional name: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• Synonyms: Colchiceine methyl ether; Colchisol; Artrichine; Colsaloid

DATABASE IDS

• CAS Number: 64-86-8

PROPERTIES

• Application(s): Immunosuppressive
• Application(s): Cytostatic
• Application(s): Antirheumatic
• Application(s): Potential HIV inhibitor
• Biological Source: Chief alkaloid from Colchicum autumnale, many other Colchicum spp., several Merendera spp., Gloriosa superba and others (Liliaceae)
• Mechanism of Action: Leukocyte migration inhibitor
• Mechanism of Action: Phagocytosis inhibitor
• Mechanism of Action: Interferes with kinin formation
• Mechanism of Action: Reduces phagocytosis with inflammatory
• Mechanism of Action: Response abatement
• Mechanism of Action: Exact mechanism unknown

REFERENCES

• J.Am.Coll.Cardiol. (26, No. 6, 1549-57, 1995)
• Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery.