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Colchicine

Catalog No. Bio-0634 Name InterBioScreen
CAS Number 64-86-8 Website http://www.ibscreen.com
M. F. C22H25NO6 Telephone +7 49652 40091
M. W. 399.437 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 1205

SYNONYMS

IUPAC name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
IUPAC Traditional name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Synonyms
Colchiceine methyl ether
Colchisol
Artrichine
Colsaloid

DATABASE IDS

CAS Number 64-86-8

PROPERTIES

Application(s) Immunosuppressive
Application(s) Cytostatic
Application(s) Antirheumatic
Application(s) Potential HIV inhibitor
Biological Source Chief alkaloid from Colchicum autumnale, many other Colchicum spp., several Merendera spp., Gloriosa superba and others (Liliaceae)
Mechanism of Action Leukocyte migration inhibitor
Mechanism of Action Phagocytosis inhibitor
Mechanism of Action Interferes with kinin formation
Mechanism of Action Reduces phagocytosis with inflammatory
Mechanism of Action Response abatement
Mechanism of Action Exact mechanism unknown

DETAILS

REFERENCES

  • J.Am.Coll.Cardiol. (26, No. 6, 1549-57, 1995)
  • Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery.