Hernandezine

• Catalog No.: Bio-0629
• CAS Number: 6681-13-6
• M. F.: C39H44N2O7
• M. W.: 652.77586

SYNONYMS

• IUPAC name: (1S,14S)-9,19,20,21,25-pentamethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^3,^6.1^8,^1^2.1^1^4,^1^8.0^2^7,^3^1.0^2^2,^3^3]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24,26,31,35-dodecaene
• IUPAC Traditional name: (1S,14S)-9,19,20,21,25-pentamethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^3,^6.1^8,^1^2.1^1^4,^1^8.0^2^7,^3^1.0^2^2,^3^3]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24,26,31,35-dodecaene

DATABASE IDS

• CAS Number: 6681-13-6

PROPERTIES

• Application(s): Shows strong antiinflammatory activity
• Application(s): Weak antineoplastic agent
• Application(s): Antiseptic
• Biological Source: Alkaloid from Thalictrum hernandezii, Thalictrum fendleri, Thalictrum podocarpum, Thalictrum rochebrunianum and other Thalictrum spp. (Ranunculaceae)
• Mechanism of Action: Inhibitor of conditioned avoidance reactions in exptl. animals
• Mechanism of Action: Calcium antagonist

REFERENCES

• Padilla, J. et al., Tetrahedron, 1962, 18, 427, (isol, uv, ir, pmr, struct)
• Battersby, A.R. et al., J.C.S., 1965, 2239, (ord)
• Shamma, M. et al., Tetrahedron, 1967, 23, 2887, (Hernandezine, Thalidezine, isol, uv, ms, pmr, struct)
• Baldas, J. et al., J.C.S. Perkin 1, 1972, 592, (ms)
• Cava, M.P. et al., Tet. Lett., 1974, 4259, (cd)