Rifampicin

• Catalog No.: Bio-0621
• CAS Number: 13292-46-1
• M. F.: C43H58N4O12
• M. W.: 822.94022

SYNONYMS

• IUPAC name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
• IUPAC Traditional name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
• Synonyms: Rifadin; Rimactane; Rifaldazine

DATABASE IDS

• CAS Number: 13292-46-1

PROPERTIES

• Application(s): Antibiotic
• Application(s): Possesses antibacterial and antitubercular props.
• Application(s): Antileprotic
• Biological Source: Prod. from Streptomyces mediterranei
• Mechanism of Action: Inhibits DNA dependent RNA polymerase activity in susceptible cells
• Mechanism of Action: RNA polymerase inhibitor

REFERENCES

• Gadret, M. et al., Acta Cryst. B, 1975, 31, 1454, (cryst struct)
• Gallo, E.G. et al., Anal. Profiles Drug Subst., 1976, 5, 467, (rev, synth, anal)
• Girling, D.T. et al., J. Antimicrob. Chemother., 1977, 3, 115, (tox, rev)
• IARC Monog., 1980, 24, 243; Suppl. 7, 71, (rev)
• Sensi, P., Chron. Drug Discovery, 1982, 1, 201, (rev)
• Sensi, P., Rev. Infect. Dis., (Suppl. 3), 1983, 5, 402, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 8227, (synonyms)
• Taguchi, M. et al., Chem. Pharm. Bull., 1988, 36, 4157, (pmr, cmr)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 937
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 197
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, RKP000