Parthenolide

• Catalog No.: Bio-0620
• CAS Number: 20554-84-1
• M. F.: C15H20O3
• M. W.: 248.3175

SYNONYMS

• IUPAC name: (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0^2,^4]tetradec-7-en-13-one
• IUPAC Traditional name: (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0^2,^4]tetradec-7-en-13-one

DATABASE IDS

• CAS Number: 20554-84-1

PROPERTIES

• Biological Source: Constit. of Chrysanthemum parthenium (feverfew) and Michelia champaca
• Application(s): Antineoplastic agent
• Application(s): Active ingredient in folk remedies used to treat migraine
• Application(s): Inhibits smooth muscle contractility
• Mechanism of Action: 5-HT antagonist
• Mechanism of Action: Interleukin-1 antagonist
• Mechanism of Action: Interleukin antagonist
• Mechanism of Action: TNF-alpha antagonist
• Mechanism of Action: Nitric oxide antagonist
• Mechanism of Action: Prostaglandin antagonist
• Mechanism of Action: Prostaglandin-E2 antagonist

REFERENCES

• Govindachari, T.R. et al., Tetrahedron, 1965, 21, 1509, (isol, struct)
• Quick, A. et al., J.C.S. Perkin 2, 1976, 465, (cryst struct)
• Ogura, M. et al., Phytochemistry, 1978, 17, 957, (isol)
• Heptinstall, S. et al., J. Pharm. Pharmacol., 1992, 44, 391, (anal)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1370
• Hay, A.J.B. et al., Br. J. Pharmacol., 1994, 112, 9, (pharmacol)
• Jacobsson, U. et al., Phytochemistry, 1995, 39, 839, (Parthenolide, pmr, cmr)
• Hendriks, H. et al., Planta Med., 1997, 63, 356-359, (Parthenolide, isol)
• Fischer, N.H. et al., Phytochemistry, 1998, 49, 559-564, (activity)