Puromycin

• Catalog No.: Bio-0596
• CAS Number: 53-79-2
• M. F.: C22H29N7O5
• M. W.: 471.50956

SYNONYMS

• IUPAC name: 2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
• IUPAC Traditional name: 2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
• Synonyms: Antibiotic CL 13900; Bacterenomycin; Achromycin; Antibiotic P 638; Stillomycin; Stylomycin; Antibiotic 3123L

DATABASE IDS

• CAS Number: 53-79-2

PROPERTIES

• Application(s): Antibiotic
• Application(s): Cytostatic
• Biological Source: Isol. from Streptomyces alboniger
• Mechanism of Action: Protein synthesis inhibitor

REFERENCES

• Porter, J.N. et al., Antibiot. Chemother. (Washington, D.C.), 1952, 2, 409, (isol)
• Waller, C.W. et al., J.A.C.S., 1953, 75, 2025, (ir, uv, struct)
• Baker, B.R. et al., J.A.C.S., 1954, 76, 4044, (synth)
• Johnson, L.F. et al., J.A.C.S., 1963, 85, 3700, (nmr, struct)
• Eggers, S.H. et al., Tet. Lett., 1966, 3271, (ms, struct)
• Nathans, D., Antibiotics (N.Y.), 1967, 1, 259, (rev)
• Hawtrey, A.O. et al., Tet. Lett., 1967, 1693, (uv)
• Daluge, S. et al., J. Med. Chem., 1972, 15, 171, (pharmacol)
• de Leeuw, H.P.M. et al., Eur. J. Biochem., 1977, 76, 209, (pmr, conformn)
• Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 143
• Narula, S.S. et al., Indian J. Biochem. Biophys., 1985, 22, 1; 1986, 23, 187, (cmr, pmr, conformn)
• Robins, M.J. et al., J.O.C., 2001, 66, 8204-8210, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AEI000; POK300