Oxolinic acid

• Catalog No.: Bio-0582
• CAS Number: 14698-29-4
• M. F.: C13H11NO5
• M. W.: 261.23014

SYNONYMS

• IUPAC name: 5-ethyl-8-oxo-2H,5H,8H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
• IUPAC Traditional name: 5-ethyl-8-oxo-2H,5H,8H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
• Synonyms: Starner; Prodoxol; Utibid

DATABASE IDS

• CAS Number: 14698-29-4

PROPERTIES

• Application(s): Antibiotic
• Application(s): Antibacterial agent effective against Proteus
• Mechanism of Action: DNA-gyrase inhibitor
• Mechanism of Action: Reported to reduce brain serotonin levels in rats
• Mechanism of Action: Reported to reduce brain HIAA levels in rats

REFERENCES

• Turner, F.J. et al., Antimicrob. Agents Chemother., 1967, 475, (props)
• Kaminsky, D. et al., J. Med. Chem., 1968, 11, 160, (synth, pharmacol)
• Crew, M.C. et al., Xenobiotica, 1971, 1, 193, (metab)
• Biere, H. et al., Annalen, 1976, 1972, (synth)
• Mitscher, L.A. et al., J. Med. Chem., 1978, 21, 485, (synth)
• Glickman, R. et al., Am. J. Hosp. Pharm., 1979, 36, 1077, (rev)
• Katritzky, A.R. et al., Org. Magn. Reson., 1981, 16, 280, (cmr)
• Smrz, R. et al., Cesk. Farm., 1983, 32, 211, (synth)
• Cygler, M. et al., Acta Cryst. C, 1985, 41, 1052, (cryst struct)
• Granik, V.G. et al., Khim.-Farm. Zh., 1987, 21, 1249; CA, 109, 22333g, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 2676, (synonyms)
• Betbeder, D. et al., Med. Sci. Res., 1988, 16, 141, (activity)
• Pesticide Manual, 9th edn., 1991, No. 9220
• Agrochemicals Handbook, 3rd edn., Royal Society of Chemistry, 1992, A1262
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 189
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, OOG000