Rifaximin

• Catalog No.: Bio-0556
• CAS Number: 80621-81-4
• M. F.: C43H51N3O11
• M. W.: 785.87854

SYNONYMS

• IUPAC name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
• IUPAC Traditional name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
• Synonyms: Rifacol; Normix; Rifaxidin

DATABASE IDS

• CAS Number: 80621-81-4

PROPERTIES

• Application(s): Antibacterial agent
• Application(s): Antibiotic
• Mechanism of Action: Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase

REFERENCES

• de Angelis, L., Drugs of the Future, 1982, 7, 260, (rev)
• Brufani, M. et al., J. Antibiot., 1984, 37, 1611, (synth, pmr, pharmacol)
• Marchi, E. et al., J. Med. Chem., 1985, 28, 960, (synth, pharmacol)
• Venturini, A.P. et al., Chemioterapia, 1986, 5, 257; 263, (pharmacol, tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 200
• Gillis, J.C. et al., Drugs, 1995, 49, 467, (rev)