Doxofylline

• Catalog No.: Bio-0530
• CAS Number: 69975-86-6
• M. F.: C11H14N4O4
• M. W.: 266.25326

SYNONYMS

• IUPAC name: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• Synonyms: Ansimar; Maxivent

DATABASE IDS

• CAS Number: 69975-86-6

PROPERTIES

• Application(s): Antitussive agent used for treatment of bronchospasm
• Mechanism of Action: The bronchodilatory effect is due to their ability to inhibit phosphodiesterase (PDE) and thus inhibit breakdown of cAMP (cyclic adenosine monophosphate)
• Mechanism of Action: Increase in cyclic AMP inhibits activation of inflammatory cells in addition to bronchodilation

REFERENCES

• U.K. Pat., 1978, Instituto Biologico Chemioterapico ABC, 1 582 510; CA, 90, 197858y, (pharmacol)
• Franzone, J.S. et al., Farmaco, Ed. Sci., 1981, 36, 220, (metab)
• Badini, C. et al., Farmaco, Ed. Sci., 1982, 37, 320, (hplc)
• Bologna, E. et al., J. Int. Med. Res., 1990, 18, 282, (pharmacokinet)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1317
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TEQ175