Zopiclone

• Catalog No.: Bio-0528
• CAS Number: 43200-80-2
• M. F.: C17H17ClN6O3
• M. W.: 388.80828

SYNONYMS

• IUPAC name: 6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
• IUPAC Traditional name: 6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
• Synonyms: Imovane; Imovance; Amoban; Zimovane

DATABASE IDS

• CAS Number: 43200-80-2

PROPERTIES

• Application(s): Sedative
• Application(s): Psychosedative
• Application(s): Tranquilizer
• Application(s): Anticonvulsant
• Mechanism of Action: The mechanism of action of zopiclone is similar to benzodiazepines, with similar effects on locomotor activity and on dopamine and serotonin turnover

REFERENCES

• Jeanmart, C. et al., C. R. Hebd. Seances Acad. Sci. Ser. C, 1978, 287, 377, (synth, pharmacol)
• Goa, K.L. et al., Drugs, 1986, 32, 48, (rev, pharmacol)
• Borea, P.A. et al., Mol. Pharmacol., 1987, 31, 334, (struct)
• Brun, J.P., Pharmacol., Biochem. Behav., 1988, 29, 831, (rev)
• Bertolasi, V. et al., J.C.S. Perkin 2, 1990, 283, (cryst struct)
• Schulz, M., Pharm. Ztg., 1991, 136, 26; 30, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 622
• Fernandez, C. et al., Clin. Pharmacokinet., 1995, 29, 431, (rev, pharmacokinet)
• Noble, S. et al., Drugs, 1998, 55, 277-302, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ZUA450