Tinidazole

• Catalog No.: Bio-0521
• CAS Number: 19387-91-8
• M. F.: C8H13N3O4S
• M. W.: 247.27152

SYNONYMS

• IUPAC name: 1-[2-(ethanesulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
• IUPAC Traditional name: 1-[2-(ethanesulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
• Synonyms: Tricolam; Glongyn; Simplotan; Bioshik; Fasigyne

DATABASE IDS

• CAS Number: 19387-91-8

PROPERTIES

• Application(s): Antitrichomonal, antimicrobial agent
• Application(s): Protozoacide
• Mechanism of Action: The nitro group of tinidazole is reduced by cell extracts of Trichomonas.
• Mechanism of Action: The free nitro radical generated as a result of this reduction may be responsible for the antiprotozoal activity

REFERENCES

• Caplar, V. et al., J. Het. Chem., 1974, 11, 1055, (synth, bibl)
• Carmine, A.A. et al., Drugs, 1982, 24, 85, (rev, pharmacol)
• Nagarajan, K. et al., Indian J. Chem., Sect. B, 1982, 21, 1006, (pmr, uv, ms)
• Reddy, K.C. et al., Indian J. Pharm. Sci., 1982, 44, 6, (synth)
• Nord, C.E. et al., J. Antimicrob. Chemother., (Eds.), Suppl. 8, 1982, 10, 1, (numerous papers)
• Chasseaud, L.F. et al., Chem. Comm., 1984, 491, (cryst struct, props)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 987
• Rao, A.K.S.B. et al., J.C.S. Perkin 1, 1989, 1352
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 528
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TGD250