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Ibuprofen

Catalog No. Bio-0448 Name InterBioScreen
CAS Number 15687-27-1 Website http://www.ibscreen.com
M. F. C13H18O2 Telephone +7 49652 40091
M. W. 206.28082 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 922

SYNONYMS

IUPAC name
2-[4-(2-methylpropyl)phenyl]propanoic acid
IUPAC Traditional name
2-[4-(2-methylpropyl)phenyl]propanoic acid
Synonyms
Brufen
Femafen; Proflex
Lidifen
Ebufac
Nurofen
Motrin
Apsifen
Codafen
Lobufen
Paxofen

DATABASE IDS

CAS Number 15687-27-1

PROPERTIES

Application(s) Non-steroidal antiinflammatory agent
Application(s) Analgesic
Application(s) Antipyretic
Mechanism of Action Cyclooxygenase (COX) inhibitor
Mechanism of Action Prostaglandin antagonist

DETAILS

REFERENCES

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  • Higgins, J.D. et al., Anal. Profiles Drug Subst., 2001, 27, 265-300, (rev)
  • Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1011B, (nmr)
  • U.K. Pat., 1964, 971 700; CA, 61, 14591, (synth, pharmacol)
  • Adams, S.S. et al., Arch. Int. Pharmacodyn. Ther., 1969, 178, 115
  • Adams, S.S. et al., Toxicol. Appl. Pharmacol., 1969, 15, 310, (metab, tox)
  • McConnell, J.F., Cryst. Struct. Commun., 1974, 3, 73, (cryst struct)
  • Ger. Pat., 1975, 2 508 895; CA, 84, 5394, (lysine, salt)
  • Kaiser, D.G. et al., J. Pharm. Sci., 1976, 65, 269, (resoln, glc, bibl)
  • Shiori, T. et al., J.O.C., 1978, 43, 2936, (synth)
  • Nicholson, J.S., Chron. Drug Discovery, 1982, 1, 149, (rev)
  • Ghislandi, V. et al., Farmaco, Ed. Sci., 1982, 37, 81, (abs config)
  • Gruber, K. et al., Arzneim.-Forsch., 1983, 33, 1176, (pharmacol, tox)
  • Hiyama, T. et al., Synthesis, 1986, 645, (synth)
  • Yamauchi, T. et al., Synthesis, 1986, 1044, (synth)
  • Nicoll-Griffith, D.A., J. Chromatogr., 1987, 402, 179, (resoln)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 2867, (synonyms)
  • Eur. Pat., 1988, Gist-Brocades; Shell Int. Res., 274 146; CA, 110, 113203, (dexibuprofen lysine)
  • Wolber, E.K.A. et al., Chem. Ber., 1991, 124, 1667, (synth, pmr)
  • Gonzalez, A., Synth. Commun., 1991, 21, 1353, (synth)
  • Freer, A.A., Acta Cryst. C, 1993, 49, 1378, (cryst struct)
  • Sonawane, H.R. et al., Tetrahedron, 1994, 50, 1243, (synth)
  • Lalonde, J.J. et al., J.A.C.S., 1995, 117, 6845, (resoln)
  • Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 50
  • Shankland, N. et al., Acta Cryst. C, 1997, 53, 951-954, (cryst struct)