Clotrimazole

• Catalog No.: Bio-0442
• CAS Number: 23593-75-1
• M. F.: C22H17ClN2
• M. W.: 344.83678

SYNONYMS

• IUPAC name: 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
• IUPAC Traditional name: 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

DATABASE IDS

• CAS Number: 23593-75-1

PROPERTIES

• Application(s): Antifungal agent
• Mechanism of Action: Potent cytochrome P-450b and P-450c inhibitor
• Mechanism of Action: Functions as Lanosterol C-14 demethylation inhibitor
• Mechanism of Action: Induces K+ release from Trichophyton mentagrophytes mycelium
• Mechanism of Action: Induces membrane disruption
• Mechanism of Action: Appears to increase permeability of fungal-cell-membrane causing leakage of intracellular components.

REFERENCES

• Buechel, K.H. et al., Arzneim.-Forsch., 1972, 22, 1260, (synth, pharmacol)
• Kracmar, J. et al., Cesk. Farm., 1977, 26, 345, (uv)
• Raab, W., Curr. Ther. Res., Clin. Exp., 1977, 22, 65, (pharmacol)
• Ruppert, J.F., Diss. Abstr. Int., B, 1977, 38, 2681, (synth)
• Hoogerheide, J.G. et al., Anal. Profiles Drug Subst., 1982, 11, 225, (rev)
• Lewis, D.F.V. et al., J. Biochem. Toxicol., 1989, 4, 231, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 320
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 8792
• Song, H. et al., Acta Cryst. C, 1998, 54, 1675-1677, (cryst struct)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MRX500