Isbufylline

• Catalog No.: Bio-0434
• CAS Number: 90162-60-0
• M. F.: C11H16N4O2
• M. W.: 236.27034

SYNONYMS

• IUPAC name: 1,3-dimethyl-7-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 1,3-dimethyl-7-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• Synonyms: N -(2-Methylpropyl); 7-Isobutyltheophylline; Theophylline

DATABASE IDS

• CAS Number: 90162-60-0

PROPERTIES

• Application(s): Bronchodilator
• Application(s): Antiasthmatic
• Mechanism of Action: Adenosine receptor antagonist
• Mechanism of Action: CNS-stimulant
• Mechanism of Action: Purine antagonist
• Mechanism of Action: Phosphodiesterase inhibitor
• Mechanism of Action: Gastric-secretion stimulator
• Mechanism of Action: Causes accumulation of cyclic-AMP

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 214B, (nmr)
• Blout, E.R. et al., J.A.C.S., 1950, 72, 479, (ir)
• Spiteller, G. et al., Monatsh. Chem., 1962, 93, 632, (ms)
• Twanmoh, L.-M. et al., J. Het. Chem., 1973, 10, 187, (pmr)
• Takayama, S. et al., Chem. Pharm. Bull., 1974, 22, 1200, (synth, uv)
• Nicolau, C. et al., Z. Naturforsch., C, 1974, 29, 475, (cmr)
• Cohen, J.L., Anal. Profiles Drug Subst., 1975, 4, 466, (rev, ir, pmr, uv, ms, anal)
• Goeber, B. et al., Pharmazie, 1978, 33, 717, (ms)
• Naqvi, A.A. et al., J. Appl. Crystallogr., 1981, 14, 464, (cryst struct)
• Nishijo, J. et al., Chem. Pharm. Bull., 1982, 30, 391, (salts)
• Belg. Pat., 1983, 897 492; CA, 100, 209534e, (Isbufylline, synth)
• Bukowsky, M. et al., Ann. Intern. Med., 1984, 101, 63, (rev, pharmacol)
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• Manzini, S. et al., Arzneim.-Forsch., 1990, 40, 1205, (Isbufylline, pharmacol)
• Atta-ur-Rahman et al., The Alkaloids, 1990, 38, 232, (spectra)
• IARC Monog., 1991, 51, 391, (rev, tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1314; 1315; 1319
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 793, (synonyms)
• Ebisuzaki, Y. et al., Acta Cryst. C, 1997, 53, 777-779, (cryst struct)
• Markham, A. et al., Drugs, 1998, 56, 1081-1091, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TEP000; TEP500