Clopamide

• Catalog No.: Bio-0415
• CAS Number: 636-54-4
• M. F.: C14H20ClN3O3S
• M. W.: 345.8449

SYNONYMS

• IUPAC name: 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide
• IUPAC Traditional name: 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide
• Synonyms: Chlosudimeprinyl; Aquex; Adurix; Brinaldix

DATABASE IDS

• CAS Number: 636-54-4

PROPERTIES

• Application(s): Diuretic
• Application(s): Antihypertensive
• Description: cis-izomers
• Mechanism of Action: Inhibitor of the sodium-chloride cotransport
• Mechanism of Action: Acts at the Proximal Convoluted tubule site of the nephron
• Mechanism of Action: Selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus
• Mechanism of Action: intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl

REFERENCES

• Jucker, E. et al., Helv. Chim. Acta, 1962, 45, 2316, (synth, ir)
• Doerling, H.J. et al., Arzneim.-Forsch., 1966, 16, 1183; 1197, (pharmacol)
• Terry, B. et al., J. Pharmacol. Exp. Ther., 1968, 160, 367, (pharmacol)
• Kracmar, J. et al., Pharmazie, 1975, 30, 447, (uv)
• McNeil, J.J. et al., Clin. Pharmacol. Ther. (St. Louis), 1987, 42, 299, (pharmacokinet)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 813