Sulfalene

• Catalog No.: Bio-0403
• CAS Number: 152-47-6
• M. F.: C11H12N4O3S
• M. W.: 280.30298

SYNONYMS

• IUPAC name: 4-amino-N-(3-methoxypyrazin-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-(3-methoxypyrazin-2-yl)benzene-1-sulfonamide
• Synonyms: Kelfizine; Sulfamethoxypyrazine; Dalysep; Longum; Polycidal

DATABASE IDS

• CAS Number: 152-47-6

PROPERTIES

• Application(s): Antiseptic
• Application(s): Long-acting sulfonamide used in treatment of respiratory and urinary-tract infections
• Mechanism of Action: Competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase
• Mechanism of Action: The inhibited reaction is necessary in these organisms for the synthesis of folic acid

REFERENCES

• Launchbury, A.P., Pharm. J., 1975, 214, 14, (pharmacol)
• Kracmar, J. et al., Pharmazie, 1975, 30, 447, (uv)
• Padeiskaya, E.N. et al., Khim.-Farm. Zh., 1977, 11, 141, (rev, pharmacol)
• Botta, M. et al., J. Het. Chem., 1979, 16, 193, (synth)
• Anisimova, O.S. et al., Khim.-Farm. Zh., 1980, 14, 92, (ms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 205
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MFN500