Triclabendazole

• Catalog No.: Bio-0402
• CAS Number: 68786-66-3
• M. F.: C14H9Cl3N2OS
• M. W.: 359.65806

SYNONYMS

• IUPAC name: 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole
• IUPAC Traditional name: 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole
• Synonyms: Fasinex

DATABASE IDS

• CAS Number: 68786-66-3

PROPERTIES

• Application(s): Anthelmintic (with active sulfoxide metabolite)
• Description: Tautomers (~1:1)
• Mechanism of Action: Binds to beta-tubulin and prevent the polymerisation of the microtubules of which they are part

REFERENCES

• Ger. Pat., 1978, Ciba-Geigy, 2 815 621; CA, 90, 38919c, (synth, pharmacol)
• Negro, A. et al., J. Chromatogr., 1992, 576, 135, (hplc)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 55
• Stitt, A.W. et al., Parasitol. Res., 1993, 79, 529, (pharmacol)
• Martin, P.A. et al., Vet. Rec., 1993, 133, 300, (tox)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CFL200