Albendazole sulfone

• Catalog No.: Bio-0400
• CAS Number: 75184-71-3
• M. F.: C12H15N3O4S
• M. W.: 297.3302

SYNONYMS

• IUPAC name: methyl N-[5-(propane-1-sulfonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC Traditional name: methyl N-[5-(propane-1-sulfonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• Synonyms: Alben; Valbazen; Helmintal; Zentel; Bermosol; Eskazole

DATABASE IDS

• CAS Number: 75184-71-3

PROPERTIES

• Application(s): Anthelmintic
• Application(s): Investigated for treatment of chronic stronglyoidiasis, and for microsporidiosis in AIDS patients
• Mechanism of Action: Causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin,
• Mechanism of Action: thus inhibiting its polymerization or assembly into microtubules.
• Mechanism of Action: The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores.
• Mechanism of Action: Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP),
• Mechanism of Action: which is the energy required for the survival of the helminth.
• Mechanism of Action: Due to diminished energy production, the parasite is immobilized and eventually dies.
• Mechanism of Action: Also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific.
• Mechanism of Action: This action may be considered secondary to the effect

REFERENCES

• U.S. Pat., 1975, SmithKline, 3 915 986; CA, 84, 31074r, (synth, pharmacol)
• Theodorides, V.J. et al., Experientia, 1976, 32, 702, (pharmacol)
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• Gyurik, R.J. et al., Drug Metab. Dispos., 1981, 9, 503, (metab)
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• Firth, M., Int. Congr. Symp. Ser. R. Soc. Med., (Ed.), No. 61, 1984, (book)
• Delatour, P. et al., Xenobiotica, 1991, 21, 217, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 38
• Archibald, L.K. et al., Quart. J. Med., 1993, 86, 191, (use)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 2970, (synonyms)
• Oldfield, E.C., Am. J. Gastroenterol., 1995, 90, 159, (use)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VAD000