Phenytoin

• Catalog No.: Bio-0370
• CAS Number: 57-41-0
• M. F.: C15H12N2O2
• M. W.: 252.26798

SYNONYMS

• IUPAC name: 5,5-diphenylimidazolidine-2,4-dione
• IUPAC Traditional name: 5,5-diphenylimidazolidine-2,4-dione
• Synonyms: Phenhydan; Di-Hydan; Fenytoine; Zentropil; Fenitoin; Aleviatin; Epanutin; Epsolin; Fenantoin; Pentran; Phenantoin; Pyoredol

DATABASE IDS

• CAS Number: 57-41-0

PROPERTIES

• Application(s): Anticonvulsant
• Application(s): Antiepileptic (veterinary product)
• Mechanism of Action: Apparent motor cortex depressant
• Mechanism of Action: Reduces posttetanic potentiation at synapses preventing cortical seizure foci from detonating adjacent cortical areas
• Mechanism of Action: Reduces the maximal activity of brain-stem centers responsible for the tonic-phase of grand-mal seizures
• Mechanism of Action: May promote neuronal sodium-efflux so stabilizing threshold against hyperexcitability caused by events capable of reducing membrane sodium gradient
• Mechanism of Action: Apparent primary site of action is motor-cortex where spread of seizure activity is inhibited

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 398C, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1446C, (nmr)
• Camerman, A. et al., Acta Cryst. B, 1971, 27, 2205, (cryst struct)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1971, 304, 883, (ms)
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• Goenechea, S., Mikrochim. Acta, 1972, 276, (ir)
• Long, R.C. et al., J. Magn. Reson., 1974, 16, 228, (nmr)
• Simig, G. et al., Tetrahedron, 1975, 31, 1195, (synth)
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