Andrographolide

• Catalog No.: Bio-0337
• CAS Number: 5508-58-7
• M. F.: C20H30O5
• M. W.: 350.4492

SYNONYMS

• IUPAC name: (3E)-3-{2-[(5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}-4-hydroxyoxolan-2-one
• IUPAC Traditional name: (3E)-3-{2-[(5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}-4-hydroxyoxolan-2-one

DATABASE IDS

• CAS Number: 5508-58-7

PROPERTIES

• Application(s): Hepatoprotective
• Application(s): Cardioprotective
• Application(s): Shown to be effective against certain cancers and is an effective purgative
• Biological Source: Constit. of Andrographis paniculata
• Mechanism of Action: Activator of alpha-1A-adrenoceptor
• Mechanism of Action: Suppressor of the expression of inducible nitric oxide synthase
• Mechanism of Action: Prevents oxygen radical production by human neutrophils

REFERENCES

• Habtemariam, S. et al., Phytother. Res., 1998, 12, 37-40, (Andrographolide, activity)
• Singh, M. et al., Planta Med., 1999, 65, 2-8, (review)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 1135C, (nmr)
• Talukdar, P.B. et al., Indian J. Chem., 1968, 6, 252, (isol)
• Patra, A. et al., Org. Magn. Reson., 1981, 16, 74; 17, 301, (cmr)
• Fujita, T. et al., Chem. Pharm. Bull., 1984, 32, 2117, (cryst struct)
• Matsuda, T. et al., Chem. Pharm. Bull., 1994, 42, 1216-1225, (isol, pmr, cmr, activity)