Thujaplicin-Beta

• Catalog No.: Bio-0320
• CAS Number: 499-44-5
• M. F.: C10H12O2
• M. W.: 164.20108

SYNONYMS

• IUPAC name: 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
• IUPAC Traditional name: 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
• Synonyms: Hinokitiol

DATABASE IDS

• CAS Number: 499-44-5

PROPERTIES

• Application(s): Phytoncide
• Application(s): Tuberculostatic
• Application(s): Cytostatic
• Biological Source: Occurs in Juniperus conferta and the heartwood of Thuja plicata . Also from Thuja occidentalis, Thuja dolabrata, Thuja standishii, Cupressus spp., and Juniperus spp.
• Mechanism of Action: Tyrosinase and carboxypeptidase A inhibitor

REFERENCES

• Anderson, A.B. et al., Acta Chem. Scand., 1948, 2, 644, (isol, struct)
• Tanaka, K. et al., Tetrahedron, 1971, 27, 4889, (synth)
• Derry, J.E. et al., J.C.S. Perkin 2, 1972, 694, (cryst struct)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, no. 573, (occur)
• Noyori, R. et al., J.O.C., 1975, 40, 806, (synth)
• Tamura, Y. et al., Tet. Lett., 1977, 4075, (synth)
• Neumann, M. et al., Tet. Lett., 1978, 5033, (synth)
• Miyashita, M. et al., J.O.C., 1987, 52, 2602, (synth)
• Banwell, M.G. et al., Aust. J. Chem., 1991, 44, 705, (synth)
• Ohishi, H. et al., Acta Cryst. C, 1994, 50, 587, (cryst struct, bibl)
• Madar, Z. et al., Phytochemistry, 1995, 38, 351, (Cupressotropolone A)
• Ono, M. et al., Biosci., Biotechnol., Biochem., 1998, 62, 1653-1659, (prodn)
• Yoshihiko, I. et al., Biol. Pharm. Bull., 1999, 22, 990-993, (activity)
• Yamaguchi, T. et al., J. Wood Sci., 1999, 45, 170-173; CA, 131, 127604, (activity)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, IRR000