Costunolide

• Catalog No.: Bio-0308
• CAS Number: 553-21-9
• M. F.: C15H20O2
• M. W.: 232.3181

SYNONYMS

• IUPAC name: (3aS,11aR)-6,10-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,8H,9H,11aH-cyclodeca[b]furan-2-one
• IUPAC Traditional name: (3aS,11aR)-6,10-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,8H,9H,11aH-cyclodeca[b]furan-2-one

DATABASE IDS

• CAS Number: 553-21-9

PROPERTIES

• Application(s): Shows antimycobacterial activity
• Biological Source: Constit. of costus root (Saussurea lappa) and Artemisia balchanorum. Also from Talauma mexicana and Cosmos sulphureus
• Mechanism of Action: Suppressive on cytotoxic T lymphocytes
• Mechanism of Action: Effective HO-1 inducer inhibiting macrophage-derived pro-inflammatory cytokines
• Mechanism of Action: Activator of Nrf2 leading to HO-1 expression

REFERENCES

• Rao, A.S. et al., Tetrahedron, 1960, 9, 275, (isol)
• Bouill, M.J. et al., Acta Cryst. B, 1976, 32, 3203, (cryst struct)
• Kanasaki, T. et al., Agric. Biol. Chem., 1976, 40, 1239
• Grieco, P.A. et al., J.O.C., 1977, 42, 1717, (synth)
• Shibuya, H. et al., Chem. Lett., 1986, 85, (synth)
• Takahashi, T. et al., Tetrahedron, 1987, 43, 5499, (synth)
• Banerjee, A.K. et al., Tetrahedron, 1993, 49, 4761, (synth, rev)
• Taniguchi, M. et al., Biosci., Biotechnol., Biochem., 1995, 59, 2064-2067, (activity)
• Jacobsson, U. et al., Phytochemistry, 1995, 39, 839, (Costunolide, pmr, cmr)
• Park, H.-J. et al., J. Nat. Prod., 1996, 59, 1128, (Costunolide, pmr, cmr)
• Fischer, N.H. et al., Phytochemistry, 1998, 49, 559-564, (activity)
• Jang, D.S. et al., Saengyak Hakhoechi, 1998, 29, 67-70, (activity)